What is the Effect of Sequence Error on Polyampholyte Self-coacervation?

Polyampholytes can undergo a macroscopic, associative phase transition in solution known as complex coacervation. There has been a significant effort to understand the underlying physics behind this transition – with most current theories growing out of the Voorn – Overbeek Theory (VOT). This theory; however, has major issues in completely resolving the molecular features that play a huge role in the thermodynamics of coacervation. Our lab has demonstrated a way of better understanding this complex process through simulation of polyampholyte polymers. Now, we would like to see how introducing “experimental” or random error into such simulations affect the thermodynamics of such material.