Exposure to water disinfection by-products (DBPs) has been linked to various harmful effects on human health. However, there have been very few studies conducted on the effects of iodoacetic acid (IAA) on reproductive health outcomes. This study will analyze the effects of IAA on mouse uteri, specifically on cell proliferation, uterine morphology, and stromal cell viability. Uteri will be obtained from mice that were dosed with five different concentrations of IAA (0, 0.5 mg/L, 10 mg/L, 100 mg/L, 500 mg/L). Hematoxylin-eosin (H&E), and immunohistochemistry (IHC) staining will be conducted on the uterine tissue. Uterine morphology (lumen area, lumen perimeter, endometrium area, endometrium diameter, inner/outer myometrium height and thickness, and cross-section diameter) will be measured using H&E stained uteri. The proliferation marker, Ki67, will be used in the IHC staining to measure cell proliferation within the luminal epithelium and stroma. Cell culture will be conducted using primary stromal cells from the endometrium of mice uteri. The stromal cells will be placed in three different treatment groups (DMSO control, 2 μM IAA, 15 μM IAA) for 48 and 96 hours. An MTT assay will also be conducted on stromal cells treated with IAA to measure cell viability. For this study, I hypothesized that exposure to a relevant level of IAA will decrease the level of cell proliferation, decrease cell viability, and modify the morphology of the uteri. Results of this study show that cell viability and number significantly decreased in cultured stromal cells exposed to IAA at concentrations of 2μM and 15 μM. IAA exposure for 30 days did not significantly affect uterine morphology or proliferation in the stromal cells.