Angiogenesis in Healthy vs. Diabetic Mice Imaged Using Pulsed Power Doppler Ultrasound

Diabetic neuropathy affects 14 million Americans causing pain, loss of sensation, and other symptoms. A diabetic patient may lack angiogenesis, the ability to regrow capillaries at a normal rate following microvasculature injury, eventually contributing to claudication and neuropathy. Existing methods to study neuropathy are magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound. In this study, we developed and applied novel ultrasonic imaging and analysis methods, pulsed power Doppler ultrasound with higher order singular value decomposition, to image blood perfusion in a metabolically healthy ischemic murine model. We believe that our research, once completed, has the potential to image blood perfusion in an ischemic murine model to compare angiogenesis rates in diabetic and healthy mice by developing and applying novel ultrasonic imaging and analysis methods.

Author
Cheri McChesney
School
Robert Morris University
Department
Biomedical Engineering
Research Advisor
Dr. Mike Insana
Department of Research Advisor
Bioengineering
Year of Publication
2019